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KMID : 0882420160910010088
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Korean Journal of Medicine
2016 Volume.91 No. 1 p.88 ~ p.91
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Fatal Hemophagocytic Lymphohistiocytosis associated with Influenza B
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Lee Saem-Na
Yoon Jin-Gu
Cho Chi-Hyun
Choi Chul-Won
Choi Jung-Yoon
Cheong Hee-Jin
Kim Woo-Joo
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Abstract
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Influenza infection may be complicated by various infectious or non-infectious diseases. Among them, hemophagocytic lymphohistiocytosis (HLH) is an uncommon hyperinflammatory syndrome caused by uncontrolled proliferation and activation of macrophages and lymphocytes, and it is often life threatening. A previously healthy male patient was suspected to have HLH after influenza B infection. The diagnosis was established based on clinical diagnostic criteria suggested in the HLH-2004 trial. Despite prompt antiviral therapy, the patient expired on day 19 of hospitalization. Influenza can thus be complicated by HLH. Due to the non-specific manifestations of HLH, clinical suspicion and early diagnosis are important.
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KEYWORD
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Influenza B, Lymphohistiocytosis, Hemophagocytic
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